Antibodies synthesis: peptide antigens for antibody generation

Peptide antigens

AltaBioscience specialise in synthesising custom peptide antigens for use in antibody production and custom antibody generation.

Synthetic peptides as immunogens have proven advantages over protein immunogens. By themselves, peptides are too small to elicit an immune response so must be presented as larger entities in order for the body to detect them and produce an antigenic response. Our peptide antigen service offers two methods of peptide antigen production:

• Multiple antigenic peptides (MAPS)
• Peptide-protein conjugation to proteins

Suitable for both a monoclonal antibody production and polyclonal antibody production, our peptide synthesis experts can assist with peptide antigen design using our epitope design software thereby suggesting antigenic peptide regions likely to provide the best immune response.

For purification, we can supply our ready to use reusable affinity columns, designed by AltaBioscience, which have your peptide antigen immobilised on a solid support ready for polyclonal antibody purification.

Antibody Peptide Synthesis with Altabioscience

All our peptide-protein antigens are purified by dialysis ready for use in antibody production.
Whether you select MAPS synthesis or peptide-protein carrier conjugations for your immunogen program, we can also provide unconjugated linear peptides for use in blocking assays.

Antibody Peptide

With expertise spanning more than 45 years, our peptide chemists can assist with the design of peptide antigens. Using our software designed in-house, we look at both the antigenic potential of epitopes along the protein and also take into consideration the synthesis implications required for each specific peptide sequence identified.

For selection we aim to include flexible regions including both hydrophilic and hydrophobic amino acids ensuring that a significant percentage of charged residues such as Lys, Arg, Glu and Asp can be incorporated avoiding where possible any highly hydrophobic regions.

Our laboratory has developed the technology to make peptides covalently bound to controlled pore glass, (Peptide – CPG) for use as affinity columns. This material has many advantages over other types of support, it has good flow rates, is mechanically and chemically very robust with almost an indefinite lifetime.

Get in touch today

For more information about our custom synthesis services, or to request a copy of our technical brochure, please contact us below:

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